The main factors which had significant effects on the synthesis of carbonated polypropylene glycol diglycidyl ether (5CC-PPGDGE) were investigated by using uniform design. The 5CC-PPGDGE was synthesized from polypropylene glycol diglycidyl ether (PPGDGE) and CO2 by using quaternary ammonium salt modified amberlyst D296 as catalyst. Effect of D296 catalyst content, reaction time, reaction temperature, reaction pressure and catalyst activation time on conversion efficiency of PPGDGE were investigated. By two uniform design experiments, the main factors for PPGDGE conversion were determined: catalyst content = 12 %, reaction time = 38 h, reaction temperature = 125 ℃, reaction pressure= 1 MPa and catalyst activation time = 24 h, and the optimum conditions were obtained based on the relationship between experimental factors and conversion which was acquired through regression. The conversion of product from the optimum condition was almost 100 % and product was confirmed by FTIR, 1HNMR, 13CNMR, GPC and TGA analysis.