La modified Cu-Fe/SiO2was prepared by ultrasound assisted impregnation. The effect of rare earth La additional on the catalytic performance of Cu-Fe/SiO2 was investigated. The catalysts were systematically characterized by techniques of X-ray diffraction (XRD), N2 adsorption isotherm, temperature-programmed desorption of CO (CO-TPD), and temperature-programmed reduction of H2 (H2-TPR), meanwhile the catalytic performance for CO hydrogenation to higher alcohols was also evaluated. The experimental results showed that with the modification of La, promoted the dispersion of active sites, the specific surface area was increased notably, enhanced adsorption capacity of CO and decreased reducibility of active sites. Therefore, the modified catalyst obviously improved the higher selectivity to C2 alcohols, and the content of methanol in reaction product was reduced significantly.