Using polycaprolactone diol (PCL), toluene diisocyanate (TDI) and methyl methacrylate ( MMA ) as main raw materials, waterborne polyurethane-acrylate emulsion (WPUA ) prepolymer was synthesized. the product obtained by coupling modified nano - SiO2 with graphene oxide was polymerized in situ with the prepolymer. at the same time, carboxylic acid hydrophilic chain extender and sulfonic acid hydrophilic chain extender were used to prepare functionalized graphene-modified waterborne polyurethane-acrylate composite emulsion ( SiO2-NH2-go/ WPUA ) with solvent-free and zero VOC characteristics by self-emulsifying method .Compared with waterborne polyurethane-acrylate ( WPUA ), the composite emulsion ( SiO2-NH2-go/ WPUA) has better temperature resistance and film properties. when the mass fraction of SiO2-NH2-go is 0.75 %, the thermal decomposition temperature of the composite emulsion film is 77.32 ℃ higher than that of the unmodified emulsion film;The tensile strength increased to 81.28 MPa;and the T- peel strength of the adhesive prepared by the composite emulsion reached 15.4 N in aluminum foil / PVC film;Indicators such as easy oxides meet the standards for pharmaceutical packaging containers, indicating that the waterborne polyurethane adhesive is suitable for pharmaceutical packaging.