Inexpensive acetamide (CH3CONH2)-based ionic liquids were synthesized by coordinating CH3CONH2 with anhydrous ZnCl2 at a molar ratio of 1:0.3, 1:0.4, 1:0.5, and its structure was characterized with FT-IR spectroscopy. The removal performance for basic and non-basic nitrogen of the ILs from model diesel oil containing quinoline and indole was studied. Experiment results showed that IL CH3CONH2-0.3ZnCl2 exhibited a better denitrogenation performance, and the removal efficiencies of quinoline and indole were 96.8% and 68.1% at temperature of 50℃, 1:3 (w/w) IL: oil, extraction time of 20min and settling time of 2h, respectively. It was found by further study that indole removal efficiency can reach 97.6 % with the IL after 4-stage extraction. Moreover, the quinoline removal efficiency can still reach 91.5% during five recycles of the IL.