In recent years, the research of organic-inorganic hybrid membranes has received extensive attention from the academic community. With the diversification of organic-inorganic hybrid membrane preparation methods and the improvement of separation performance, its research prospects are becoming more and more broad. Firstly, this article analyzes the advantages of organic-inorganic hybrid membranes compared to ordinary inorganic membranes and organic membranes in terms of structure and performance. Secondly, it summarizes the preparation methods of organic-inorganic hybrid membranes and their use in alcohols, organic acids, etc. For separation and purification applications in organic solvents or organic mixtures, the focus will be on its application in pervaporation. Finally, the research prospects of organic-inorganic hybrid membranes are prospected. Future research on organic-inorganic hybrid membranes should rely on new computational tools, focusing on material selection or improvement of preparation methods, such as exploring polymer materials with multifunctional chemical groups and porous fillers with clear hierarchical structures. The organic-inorganic hybrid membrane has a broader application prospect.