1-氨丙基-2-甲基咪唑的合成与表征
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Synthesis and characterization of 1-ammonia propyl-2-methyl imidazole
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    摘要:

    以1-氰乙基-2-甲基咪唑(2MZCN)为原料催化氢化制备1-氨丙基-2-甲基咪唑,系统讨论分析了反应过程中合成工艺参数对产物的影响,确定较为适宜的工艺条件为:温度T=100℃,压力为5MPa,转速r=624rpm,时间t=4h,溶剂是氨的饱和乙醇溶液(与原料质量比是2:1),雷尼镍为催化剂,氢氧化钾为助催化剂(占原料质量18.9%),原料的转化率可达99.7%,产率可达94.2%。采用红外光谱(FTIR)和核磁共振氢谱(1HNMR)及气质联用(GC-MS)分析对产物进行了表征。

    Abstract:

    1-ammonia propyl-2-methyl imidazole was synthetizatied from catalytic hydrogenation of 1-cyanoacetate-2-methylimidazole (2MZCN), the parameters of synthetic process were investigated systematicly .And the appropriate synthetic conditions were obtained. The conversion of 2MZCN and 1-amino-propyl-2-methyl imidazole yield reached 99.7% and 94.2% after reaction 4 h respectively, under the conditions of reaction temperature of 100℃, pressure of 5Mpa, speed of 624rpm, and the solvent is saturated ethanol solution of ammonia (ratio with the quality of raw material is 2:1), Rainie nickel is the catalytic agent and potassium hydroxide act as catalyst promoter (accounting for the quality of raw material 18.9%). The product is analysed by Infrared spectroscopy (FTIR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) and Gas Chromatography-Mass Spectrometer(GC-MS).

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郑雯,彭晓宏.1-氨丙基-2-甲基咪唑的合成与表征[J].精细化工,2013,30(11):

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  • 收稿日期:2013-04-22
  • 最后修改日期:2013-05-16
  • 录用日期:2013-05-20
  • 在线发布日期: 2013-09-29
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