Abstract：The catalyst samples of different load and different supports were prepared by equal volume impregnation method using FeCoY as active component, the catalyst was characterized by XRD, BET and H2-TPR. The experiments were investigated on aminiature fixed bed reactor about the activity of catalysts for simultaneous desulfurization and denitrification and oxidation resistance by using CO as reducing agent gas. The results show: the nitric acid pretreated catalyst can significantly improve the performance of the catalyst. The catalyst 10Fe6Co3Y/AC with the active components Fe, Co and Y respectively occupying 10%, 6% and 3% of the carrier is the best combination and the conversion rate of desulfurization and denitrification can reach 100%, The temperature at which the desulfurization and denitrification conversion rate reaches 90% at the same time is about 218 °C. XRD results shows that the catalyst has a spinel structure. The results of antioxidant experiments show that: it is preliminarily judged that the desulfurization process follows the Redox-COS synergistic mechanism, while the denitration only follows the COS mechanism., O2 with a volume fraction of 1% exhibits different toxic effects on the active sites of NO and SO2.