Two kinds of water-soluble fullerenes〔fullerene sodium hyalornate（MHAF60 and fullenene polyvinylpyrrolidone (PPF60)〕were prepared and tested for skin care .The results of GC UV-Vis and FTIR showed that fullerenes still keep their characteristic absorption .The results of DLS showed that the particle sizes of the two materials are 368.5nm and 500.6nm, respectively The results of GC showed that there was no residual organic solvent in the two materials. EPR detection showed that the free radical quenching ability of MHAF60 was significantly better than that of PPF60, vitamin C and water-soluble astaxanthin. HEK-A cells was used to test the ability of fullerene to repair oxidative damage. The results show that MHAF60 has significant protective and repairing effects on cell injury, and the effect was significantly better than that of vitamin C and water-soluble astaxanthin. The results of zebrafish experiment showed that fullerene could significantly inhibit melanin production, inhibit inflammation and promote wound healing, and higher security.