The solid base catalysts MgAl-LDO and KF/MgAl-LDO doped with different alkali metal halides(MX) were prepared by MgAl-LDHs as precursor. XRD characterization and Hammett titration were carried out, and the catalytic activity for the synthesis of anisole from phenol and dimethyl carbonate was investigated. The results showed that the Mg/Al molar ratio, precipitation pH and calcination temperature of MgAl-LDHs all affect the structure and basicity of the catalyst, and the droping of KF greatly increases the base amount of the catalyst, especially the strong base amount of H0(11-15), which is mainly provided by KMgF3 and K2CO3. The catalyst of KF/MgAl-LDO with the KF mass fraction of 33% showed the best catalytic performance. When the molar ratio of DMC to phenol was 2:1, the catalyst dosage is only 1 wt%(based on the phenol mass), reaction temperature is 200 ℃, reaction time is 4 h, the yield of anisole was 95.2%. The research of the relation between the activity and the basicity showed that the activity of the catalyst was positively correlated with the total base amount, and the strong base site of H -(11~15) had the highest catalytic performance.